FMOD

Gene Information

Official Symbol: FMOD
Official Name: fibromodulin
Aliases and Previous Symbols: N/A
Entrez ID: 2331
UniProt: Q06828
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5567
Expression level (log2 read counts): -3.59

Expression Distribution

LRR 4
LRRNT

transforming growth factor beta receptor complex assembly
keratan sulfate catabolic process
extracellular matrix structural constituent conferring compression resistance
keratan sulfate biosynthetic process
keratan sulfate metabolic process
collagen fibril organization
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Golgi lumen
transforming growth factor beta receptor signaling pathway
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
cellular response to transforming growth factor beta stimulus
glycosaminoglycan metabolic process
response to transforming growth factor beta
aminoglycan metabolic process
sulfur compound biosynthetic process
carbohydrate derivative catabolic process
transmembrane receptor protein serine/threonine kinase signaling pathway
extracellular matrix
extracellular matrix organization
collagen-containing extracellular matrix
sulfur compound metabolic process
extracellular structure organization
supramolecular fiber organization
cellular response to growth factor stimulus
response to growth factor
carbohydrate derivative biosynthetic process
enzyme linked receptor protein signaling pathway
cellular protein-containing complex assembly
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
cellular response to endogenous stimulus
organonitrogen compound biosynthetic process