FNIP2

Gene Information

Official Symbol: FNIP2
Official Name: folliculin interacting protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 57600
UniProt: Q9P278
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3, ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19003
Expression level (log2 read counts): 4.67

Expression Distribution

ATPase inhibitor activity
negative regulation of TORC1 signaling
regulation of TORC1 signaling
negative regulation of TOR signaling
negative regulation of mitochondrion organization
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of TOR signaling
chaperone binding
positive regulation of peptidyl-serine phosphorylation
regulation of peptidyl-serine phosphorylation
intrinsic apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of protein complex assembly
apoptotic signaling pathway
negative regulation of organelle organization
regulation of protein complex assembly
negative regulation of intracellular signal transduction
positive regulation of cellular component biogenesis
negative regulation of cellular component organization
cellular response to DNA damage stimulus
negative regulation of catalytic activity
negative regulation of transcription by RNA polymerase II
apoptotic process
regulation of cellular component biogenesis
protein phosphorylation
positive regulation of protein phosphorylation
programmed cell death
positive regulation of phosphorylation
cell death
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
negative regulation of molecular function
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
phosphorylation
regulation of organelle organization