FNTA [The Human Chemical-Genetic Interaction Map Project]

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======= FNTA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FNTA
  * **<color #00a2e8>Official Name</color>**: farnesyltransferase, CAAX box, alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2339|2339]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49354|P49354]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FNTA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FNTA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PPTA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of tubulin deacetylation|
|CAAX-protein geranylgeranyltransferase activity|
|protein geranylgeranyltransferase activity|
|CAAX-protein geranylgeranyltransferase complex|
|neurotransmitter receptor metabolic process|
|protein farnesyltransferase activity|
|protein farnesyltransferase complex|
|Rab geranylgeranyltransferase activity|
|protein farnesylation|
|protein geranylgeranylation|
|acetylcholine receptor regulator activity|
|skeletal muscle acetylcholine-gated channel clustering|
|positive regulation of deacetylase activity|
|regulation of tubulin deacetylation|
|prenylation|
|protein prenylation|
|regulation of deacetylase activity|
|positive regulation of protein deacetylation|
|regulation of rhodopsin mediated signaling pathway|
|postsynaptic membrane organization|
|microtubule associated complex|
|alpha-tubulin binding|
|neuromuscular junction development|
|regulation of protein deacetylation|
|receptor clustering|
|receptor tyrosine kinase binding|
|regulation of neurotransmitter receptor activity|
|localization within membrane|
|postsynapse organization|
|transforming growth factor beta receptor signaling pathway|
|receptor metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|regulation of signaling receptor activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|microtubule binding|
|synapse organization|
|protein localization to membrane|
|cellular response to growth factor stimulus|
|response to growth factor|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|membrane organization|
|regulation of response to external stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.11|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.08|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.94|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.82|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.76|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.75|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.73|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.72|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.93|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.52|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.77|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.89|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bub3|BUB3]]|0.591|
|[[:human genes:f:fntb|FNTB]]|0.579|
|[[:human genes:r:rbm14|RBM14]]|0.574|
|[[:human genes:m:mad2l1|MAD2L1]]|0.544|
|[[:human genes:k:kntc1|KNTC1]]|0.534|
|[[:human genes:t:thg1l|THG1L]]|0.531|
|[[:human genes:d:dpagt1|DPAGT1]]|0.524|
|[[:human genes:p:pelo|PELO]]|0.521|
|[[:human genes:p:pmm2|PMM2]]|0.515|
|[[:human genes:r:rnmt|RNMT]]|0.505|
|[[:human genes:t:tbca|TBCA]]|0.501|
|[[:human genes:z:zw10|ZW10]]|0.499|
|[[:human genes:m:med16|MED16]]|0.498|
|[[:human genes:t:trip13|TRIP13]]|0.494|
|[[:human genes:z:zwilch|ZWILCH]]|0.493|
|[[:human genes:r:rpp21|RPP21]]|0.493|
|[[:human genes:g:gnb1l|GNB1L]]|0.492|
|[[:human genes:r:rtcb|RTCB]]|0.491|
|[[:human genes:a:adsl|ADSL]]|0.49|
|[[:human genes:m:mad1l1|MAD1L1]]|0.487|
|[[:human genes:a:alg1|ALG1]]|0.482|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.481|
|[[:human genes:v:vezt|VEZT]]|0.478|
|[[:human genes:p:ppp4c|PPP4C]]|0.476|
|[[:human genes:t:triap1|TRIAP1]]|0.475|
|[[:human genes:d:ddx20|DDX20]]|0.471|
|[[:human genes:h:haus8|HAUS8]]|0.467|
|[[:human genes:b:bub1b|BUB1B]]|0.467|
|[[:human genes:n:nsmce1|NSMCE1]]|0.465|
|[[:human genes:a:alg13|ALG13]]|0.465|
|[[:human genes:a:atxn10|ATXN10]]|0.464|
|[[:human genes:u:uap1|UAP1]]|0.462|
|[[:human genes:t:telo2|TELO2]]|0.462|
|[[:human genes:t:tti2|TTI2]]|0.458|
|[[:human genes:a:aars|AARS]]|0.456|
|[[:human genes:t:tsen54|TSEN54]]|0.448|
|[[:human genes:y:yars|YARS]]|0.446|
|[[:human genes:t:trnt1|TRNT1]]|0.445|
|[[:human genes:c:cbfb|CBFB]]|0.444|
|[[:human genes:t:ten1|TEN1]]|0.443|
|[[:human genes:g:gemin8|GEMIN8]]|0.44|
|[[:human genes:t:tti1|TTI1]]|0.439|
|[[:human genes:c:chchd4|CHCHD4]]|0.434|
|[[:human genes:u:uhrf1|UHRF1]]|0.433|
|[[:human genes:w:wdr82|WDR82]]|0.431|
|[[:human genes:d:dohh|DOHH]]|0.43|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.429|
|[[:human genes:t:trmt5|TRMT5]]|0.429|
|[[:human genes:p:ppcs|PPCS]]|0.427|
|[[:human genes:m:med4|MED4]]|0.426|
|[[:human genes:d:dhps|DHPS]]|0.426|
|[[:human genes:g:gpn2|GPN2]]|0.424|
|[[:human genes:g:gemin5|GEMIN5]]|0.422|
|[[:human genes:g:gemin6|GEMIN6]]|0.421|
|[[:human genes:s:srp14|SRP14]]|0.42|
|[[:human genes:r:rpia|RPIA]]|0.42|
|[[:human genes:o:oraov1|ORAOV1]]|0.42|
|[[:human genes:g:gfpt1|GFPT1]]|0.42|
|[[:human genes:n:naa20|NAA20]]|0.42|
|[[:human genes:n:nae1|NAE1]]|0.419|
|[[:human genes:u:uxt|UXT]]|0.419|
|[[:human genes:g:gmppb|GMPPB]]|0.418|
|[[:human genes:t:tprkb|TPRKB]]|0.415|
|[[:human genes:a:alg2|ALG2]]|0.415|
|[[:human genes:z:zrsr2|ZRSR2]]|0.414|
|[[:human genes:u:utp23|UTP23]]|0.414|
|[[:human genes:p:paxip1|PAXIP1]]|0.413|
|[[:human genes:t:tamm41|TAMM41]]|0.413|
|[[:human genes:r:rad1|RAD1]]|0.413|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:e:elac2|ELAC2]]|0.409|
|[[:human genes:p:polr3h|POLR3H]]|0.408|
|[[:human genes:t:txnl4b|TXNL4B]]|0.408|
|[[:human genes:o:osgep|OSGEP]]|0.407|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.406|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.406|
|[[:human genes:a:arih1|ARIH1]]|0.405|
|[[:human genes:s:sgol1|SGOL1]]|0.404|
|[[:human genes:e:ercc2|ERCC2]]|0.4|
|[[:human genes:d:ddx1|DDX1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FNTA Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>