FNTA

Entrez Summary: N/A
UniProt Summary: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 52/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	3/56
cervix	0/4
colorectal	4/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	2/20
lung	5/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	1/22
urinary tract	3/29
uterus	0/5

Expression Distribution

positive regulation of tubulin deacetylation
CAAX-protein geranylgeranyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase complex
neurotransmitter receptor metabolic process
protein farnesyltransferase activity
protein farnesyltransferase complex
Rab geranylgeranyltransferase activity
protein farnesylation
protein geranylgeranylation
acetylcholine receptor regulator activity
skeletal muscle acetylcholine-gated channel clustering
positive regulation of deacetylase activity
regulation of tubulin deacetylation
prenylation
protein prenylation
regulation of deacetylase activity
positive regulation of protein deacetylation
regulation of rhodopsin mediated signaling pathway
postsynaptic membrane organization
microtubule associated complex
alpha-tubulin binding
neuromuscular junction development
regulation of protein deacetylation
receptor clustering
receptor tyrosine kinase binding
regulation of neurotransmitter receptor activity
localization within membrane
postsynapse organization
transforming growth factor beta receptor signaling pathway
receptor metabolic process
regulation of G protein-coupled receptor signaling pathway
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
regulation of signaling receptor activity
transmembrane receptor protein serine/threonine kinase signaling pathway
microtubule binding
synapse organization
protein localization to membrane
cellular response to growth factor stimulus