FOLR2 [The Human Chemical-Genetic Interaction Map Project]

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======= FOLR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOLR2
  * **<color #00a2e8>Official Name</color>**: folate receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2350|2350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14207|P14207]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOLR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOLR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of thymidylate synthase biosynthetic process|
|folic acid receptor activity|
|cellular response to folic acid|
|methotrexate binding|
|folate import across plasma membrane|
|folate transmembrane transport|
|folic acid transport|
|response to folic acid|
|folic acid binding|
|fusion of sperm to egg plasma membrane involved in single fertilization|
|vitamin transmembrane transport|
|anchored component of external side of plasma membrane|
|plasma membrane fusion|
|folic acid metabolic process|
|cellular response to vitamin|
|modified amino acid transport|
|folic acid-containing compound metabolic process|
|pteridine-containing compound metabolic process|
|vitamin transport|
|monocyte chemotaxis|
|cofactor transport|
|mononuclear cell migration|
|sperm-egg recognition|
|drug binding|
|cellular response to nutrient|
|drug transmembrane transport|
|cell-cell recognition|
|dicarboxylic acid transport|
|response to vitamin|
|water-soluble vitamin metabolic process|
|import across plasma membrane|
|dicarboxylic acid metabolic process|
|vitamin metabolic process|
|organic acid transmembrane transport|
|myeloid leukocyte migration|
|carboxylic acid transmembrane transport|
|membrane fusion|
|single fertilization|
|leukocyte chemotaxis|
|drug transport|
|fertilization|
|cellular modified amino acid metabolic process|
|signaling receptor activity|
|cellular response to acid chemical|
|cell chemotaxis|
|response to nutrient|
|cellular response to nutrient levels|
|receptor-mediated endocytosis|
|cell recognition|
|coenzyme metabolic process|
|cellular response to extracellular stimulus|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cellular response to external stimulus|
|response to acid chemical|
|cellular process involved in reproduction in multicellular organism|
|leukocyte migration|
|cellular response to drug|
|cofactor metabolic process|
|organic anion transport|
|inflammatory response|
|response to nutrient levels|
|drug metabolic process|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|endocytosis|
|anion transport|
|cellular response to organonitrogen compound|
|cell surface|
|cellular response to nitrogen compound|
|import into cell|
|cellular amide metabolic process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|cell migration|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|transmembrane transport|
|locomotion|
|defense response|
|ion transport|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|regulation of cell population proliferation|
|small molecule metabolic process|
|nitrogen compound transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18011
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOLR2 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>