FOLR2

Entrez Summary: N/A
UniProt Summary: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of thymidylate synthase biosynthetic process
folic acid receptor activity
cellular response to folic acid
methotrexate binding
folate import across plasma membrane
folate transmembrane transport
folic acid transport
response to folic acid
folic acid binding
fusion of sperm to egg plasma membrane involved in single fertilization
vitamin transmembrane transport
anchored component of external side of plasma membrane
plasma membrane fusion
folic acid metabolic process
cellular response to vitamin
modified amino acid transport
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
vitamin transport
monocyte chemotaxis
cofactor transport
mononuclear cell migration
sperm-egg recognition
drug binding
cellular response to nutrient
drug transmembrane transport
cell-cell recognition
dicarboxylic acid transport
response to vitamin
water-soluble vitamin metabolic process
import across plasma membrane
dicarboxylic acid metabolic process
vitamin metabolic process
organic acid transmembrane transport
myeloid leukocyte migration
carboxylic acid transmembrane transport
membrane fusion
single fertilization
leukocyte chemotaxis
drug transport