FOXF1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXF1
  * **<color #00a2e8>Official Name</color>**: forkhead box F1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2294|2294]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12946|Q12946]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601089|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain.  The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcription activator for a number of lung- specific genes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic ectodermal digestive tract morphogenesis|
|ectodermal digestive tract morphogenesis|
|detection of wounding|
|lateral mesodermal cell differentiation|
|right lung morphogenesis|
|right lung development|
|lateral mesoderm formation|
|lateral mesoderm morphogenesis|
|embryonic ectodermal digestive tract development|
|ectodermal digestive tract development|
|epithelial cell differentiation involved in mammary gland alveolus development|
|ductus arteriosus closure|
|mesenchyme migration|
|lung vasculature development|
|negative regulation of mast cell degranulation|
|lung lobe morphogenesis|
|lung lobe development|
|embryonic foregut morphogenesis|
|negative regulation of mast cell activation involved in immune response|
|foregut morphogenesis|
|negative regulation of myeloid leukocyte mediated immunity|
|lateral mesoderm development|
|midgut development|
|negative regulation of leukocyte degranulation|
|negative regulation of mast cell activation|
|cardiac left ventricle morphogenesis|
|venous blood vessel development|
|ureter development|
|establishment of epithelial cell apical/basal polarity|
|mammary gland epithelial cell differentiation|
|mammary gland lobule development|
|mammary gland alveolus development|
|embryonic digestive tract morphogenesis|
|polarized epithelial cell differentiation|
|trachea development|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|negative regulation of regulated secretory pathway|
|positive regulation of mesenchymal cell proliferation|
|mesodermal cell differentiation|
|epithelial tube branching involved in lung morphogenesis|
|establishment of epithelial cell polarity|
|smooth muscle cell differentiation|
|regulation of mesenchymal cell proliferation|
|negative regulation of exocytosis|
|regulation of mast cell degranulation|
|embryonic digestive tract development|
|regulation of mast cell activation involved in immune response|
|lung alveolus development|
|lung morphogenesis|
|morphogenesis of a polarized epithelium|
|endocardial cushion development|
|regulation of mast cell activation|
|establishment or maintenance of epithelial cell apical/basal polarity|
|digestive tract morphogenesis|
|establishment or maintenance of apical/basal cell polarity|
|negative regulation of leukocyte mediated immunity|
|establishment or maintenance of bipolar cell polarity|
|regulation of leukocyte degranulation|
|mesenchyme morphogenesis|
|mammary gland epithelium development|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of intracellular transport|
|artery morphogenesis|
|somitogenesis|
|mesoderm formation|
|vasculogenesis|
|mesoderm morphogenesis|
|pancreas development|
|smoothened signaling pathway|
|cardiac ventricle morphogenesis|
|somite development|
|artery development|
|tissue migration|
|segmentation|
|formation of primary germ layer|
|determination of left/right symmetry|
|establishment of cell polarity|
|detection of external stimulus|
|negative regulation of immune effector process|
|positive regulation of cell-substrate adhesion|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|cardiac chamber morphogenesis|
|mammary gland development|
|cardiac ventricle development|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|negative regulation of inflammatory response|
|digestive system development|
|negative regulation of immune response|
|gastrulation|
|morphogenesis of a branching epithelium|
|regulation of regulated secretory pathway|
|morphogenesis of a branching structure|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|negative regulation of leukocyte activation|
|respiratory system development|
|negative regulation of cell activation|
|establishment or maintenance of cell polarity|
|negative regulation of secretion by cell|
|transcription factor complex|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of cell-substrate adhesion|
|anterior/posterior pattern specification|
|positive regulation of immune effector process|
|mesenchyme development|
|regulation of exocytosis|
|negative regulation of secretion|
|muscle cell differentiation|
|heart morphogenesis|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|regionalization|
|regulation of inflammatory response|
|extracellular matrix organization|
|regulation of intracellular transport|
|negative regulation of response to external stimulus|
|in utero embryonic development|
|extracellular structure organization|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|gland development|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of immune effector process|
|muscle structure development|
|negative regulation of transport|
|blood vessel development|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of cell adhesion|
|epithelial cell differentiation|
|detection of stimulus|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|epithelium development|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.8|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.75|
|[[:results:exp453|B02 10μM R08 exp453]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3373
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXF1 Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>