FOXF1
Gene Information
- Official Symbol: FOXF1
- Official Name: forkhead box F1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2294
- UniProt: Q12946
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probable transcription activator for a number of lung- specific genes.
Pfam Domains GO Terms
Pfam Domains
| Fork head |
GO Terms
| embryonic ectodermal digestive tract morphogenesis |
| ectodermal digestive tract morphogenesis |
| detection of wounding |
| lateral mesodermal cell differentiation |
| right lung morphogenesis |
| right lung development |
| lateral mesoderm formation |
| lateral mesoderm morphogenesis |
| embryonic ectodermal digestive tract development |
| ectodermal digestive tract development |
| epithelial cell differentiation involved in mammary gland alveolus development |
| ductus arteriosus closure |
| mesenchyme migration |
| lung vasculature development |
| negative regulation of mast cell degranulation |
| lung lobe morphogenesis |
| lung lobe development |
| embryonic foregut morphogenesis |
| negative regulation of mast cell activation involved in immune response |
| foregut morphogenesis |
| negative regulation of myeloid leukocyte mediated immunity |
| lateral mesoderm development |
| midgut development |
| negative regulation of leukocyte degranulation |
| negative regulation of mast cell activation |
| cardiac left ventricle morphogenesis |
| venous blood vessel development |
| ureter development |
| establishment of epithelial cell apical/basal polarity |
| mammary gland epithelial cell differentiation |
| mammary gland lobule development |
| mammary gland alveolus development |
| embryonic digestive tract morphogenesis |
| polarized epithelial cell differentiation |
| trachea development |
| establishment of apical/basal cell polarity |
| establishment of monopolar cell polarity |
| establishment or maintenance of monopolar cell polarity |
| negative regulation of regulated secretory pathway |
| positive regulation of mesenchymal cell proliferation |
| mesodermal cell differentiation |
| epithelial tube branching involved in lung morphogenesis |
| establishment of epithelial cell polarity |
| smooth muscle cell differentiation |
| regulation of mesenchymal cell proliferation |
| negative regulation of exocytosis |
| regulation of mast cell degranulation |
| embryonic digestive tract development |
| regulation of mast cell activation involved in immune response |
| lung alveolus development |
| lung morphogenesis |
| morphogenesis of a polarized epithelium |
| endocardial cushion development |
| regulation of mast cell activation |
| establishment or maintenance of epithelial cell apical/basal polarity |
| digestive tract morphogenesis |
| establishment or maintenance of apical/basal cell polarity |
| negative regulation of leukocyte mediated immunity |
| establishment or maintenance of bipolar cell polarity |
| regulation of leukocyte degranulation |
| mesenchyme morphogenesis |
| mammary gland epithelium development |
| regulation of myeloid leukocyte mediated immunity |
| negative regulation of intracellular transport |
| artery morphogenesis |
| somitogenesis |
| mesoderm formation |
| vasculogenesis |
| mesoderm morphogenesis |
| pancreas development |
| smoothened signaling pathway |
| cardiac ventricle morphogenesis |
| somite development |
| artery development |
| tissue migration |
| segmentation |
| formation of primary germ layer |
| determination of left/right symmetry |
| establishment of cell polarity |
| detection of external stimulus |
| negative regulation of immune effector process |
| positive regulation of cell-substrate adhesion |
| determination of bilateral symmetry |
| specification of symmetry |
| mesoderm development |
| cardiac chamber morphogenesis |
| mammary gland development |
| cardiac ventricle development |
| digestive tract development |
| branching morphogenesis of an epithelial tube |
| negative regulation of inflammatory response |
| digestive system development |
| negative regulation of immune response |
| gastrulation |
| morphogenesis of a branching epithelium |
| regulation of regulated secretory pathway |
| morphogenesis of a branching structure |
| lung development |
| cardiac chamber development |
| respiratory tube development |
| negative regulation of leukocyte activation |
| respiratory system development |
| negative regulation of cell activation |
| establishment or maintenance of cell polarity |
| negative regulation of secretion by cell |
| transcription factor complex |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of cell-substrate adhesion |
| anterior/posterior pattern specification |
| positive regulation of immune effector process |
| mesenchyme development |
| regulation of exocytosis |
| negative regulation of secretion |
| muscle cell differentiation |
| heart morphogenesis |
| renal system development |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| urogenital system development |
| regionalization |
| regulation of inflammatory response |
| extracellular matrix organization |
| regulation of intracellular transport |
| negative regulation of response to external stimulus |
| in utero embryonic development |
| extracellular structure organization |
| positive regulation of cell adhesion |
| blood vessel morphogenesis |
| gland development |
| sequence-specific DNA binding |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of immune effector process |
| muscle structure development |
| negative regulation of transport |
| blood vessel development |
| positive regulation of cell migration |
| cell-cell adhesion |
| vasculature development |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| regulation of leukocyte activation |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of cell adhesion |
| epithelial cell differentiation |
| detection of stimulus |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| regulation of response to external stimulus |
| response to cytokine |
| epithelium development |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| iCRT14 30μM R08 exp492 | -1.8 |
| Ethanol 0.01 R05 exp234 | 1.75 |
| B02 10μM R08 exp453 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 3/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3373
- Expression level (log2 read counts): -2.21
Expression Distribution
FOXF1 Expression in NALM6 Cells: -2.21
