FOXJ2

Gene Information

Official Symbol: FOXJ2
Official Name: forkhead box J2
Aliases and Previous Symbols: N/A
Entrez ID: 55810
UniProt: Q9P0K8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9565
Expression level (log2 read counts): 5.03

Expression Distribution

Screen	Score
Nifuroxazide 5μM R03 exp102	-2.02
Rapamycin 0.001μM R08 exp429	1.88

regulation of blood vessel endothelial cell differentiation
negative regulation of blood vessel endothelial cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of vascular smooth muscle cell proliferation
regulation of endothelial cell differentiation
negative regulation of epithelial cell differentiation
regulation of vascular smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
regulation of smooth muscle cell proliferation
fibrillar center
regulation of epithelial cell differentiation
regulation of angiogenesis
regulation of vasculature development
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of cell differentiation
positive regulation of cell population proliferation
negative regulation of developmental process
regulation of anatomical structure morphogenesis
identical protein binding
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process