FOXL1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXL1
  * **<color #00a2e8>Official Name</color>**: forkhead box L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2300|2300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12952|Q12952]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|visceral mesoderm-endoderm interaction involved in midgut development|
|Peyers patch morphogenesis|
|Peyers patch development|
|mucosal-associated lymphoid tissue development|
|midgut development|
|DNA binding, bending|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|digestive tract development|
|digestive system development|
|glycoprotein biosynthetic process|
|regulation of Wnt signaling pathway|
|glycoprotein metabolic process|
|sequence-specific DNA binding|
|heart development|
|tissue morphogenesis|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|immune system development|
|DNA-binding transcription factor activity|
|tube development|
|circulatory system development|
|carbohydrate derivative metabolic process|
|cell-cell signaling|
|organonitrogen compound biosynthetic process|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.96|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.72|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXL1 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>