FOXL1

Entrez Summary: This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012].
UniProt Summary: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

visceral mesoderm-endoderm interaction involved in midgut development
Peyers patch morphogenesis
Peyers patch development
mucosal-associated lymphoid tissue development
midgut development
DNA binding, bending
proteoglycan biosynthetic process
proteoglycan metabolic process
digestive tract development
digestive system development
glycoprotein biosynthetic process
regulation of Wnt signaling pathway
glycoprotein metabolic process
sequence-specific DNA binding
heart development
tissue morphogenesis
hematopoietic or lymphoid organ development
carbohydrate derivative biosynthetic process
immune system development
DNA-binding transcription factor activity
tube development
circulatory system development
carbohydrate derivative metabolic process
cell-cell signaling
organonitrogen compound biosynthetic process
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular macromolecule biosynthetic process
tissue development
macromolecule biosynthetic process