FOXM1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXM1
  * **<color #00a2e8>Official Name</color>**: forkhead box M1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2305|2305]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08050|Q08050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602341|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|negative regulation of cell aging|
|positive regulation of double-strand break repair|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|regulation of cell aging|
|positive regulation of DNA repair|
|regulation of double-strand break repair|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of response to DNA damage stimulus|
|signal transduction in response to DNA damage|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|regulation of DNA repair|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|negative regulation of MAPK cascade|
|regulation of reactive oxygen species metabolic process|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of Ras protein signal transduction|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of small GTPase mediated signal transduction|
|regulation of DNA metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|protein kinase binding|
|negative regulation of intracellular signal transduction|
|DNA repair|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.07|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.79|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.75|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.74|
|[[:results:exp539|42°C R08 exp539]]|1.77|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXM1 Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>