FOXM1

Gene Information

Official Symbol: FOXM1
Official Name: forkhead box M1
Aliases and Previous Symbols: N/A
Entrez ID: 2305
UniProt: Q08050
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
UniProt Summary: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.2μM R00 exp24	-2.07
RO-3307 4.7μM R02 exp80	-1.79
Arsenic trioxide 60μM R08 exp449	-1.78
GSK461364A 0.005μM R03 exp125	-1.75
S-trityl-L-cysteine 0.5μM R05 exp243	1.74
42°C R08 exp539	1.77
Deferoxamine 11μM R07 exp350	2.04

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6685
Expression level (log2 read counts): 6.65

Expression Distribution

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA damage response, signal transduction resulting in transcription
negative regulation of cell aging
positive regulation of double-strand break repair
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
regulation of cell aging
positive regulation of DNA repair
regulation of double-strand break repair
DNA damage response, signal transduction by p53 class mediator
positive regulation of response to DNA damage stimulus
signal transduction in response to DNA damage
regulation of cell cycle arrest
signal transduction by p53 class mediator
regulation of DNA repair
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
negative regulation of MAPK cascade
regulation of reactive oxygen species metabolic process
positive regulation of DNA metabolic process
regulation of response to DNA damage stimulus
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of Ras protein signal transduction
DNA-binding transcription repressor activity, RNA polymerase II-specific
mitotic cell cycle phase transition
cell cycle phase transition
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of small GTPase mediated signal transduction
regulation of DNA metabolic process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
negative regulation of intracellular signal transduction
DNA repair
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mitotic cell cycle process
mitotic cell cycle