FOXO3
Gene Information
- Official Symbol: FOXO3
- Official Name: forkhead box O3
- Aliases and Previous Symbols: N/A
- Entrez ID: 2309
- UniProt: O43524
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.
Pfam Domains GO Terms
Pfam Domains
| Fork head |
GO Terms
| mitochondrial sequence-specific DNA-binding transcription factor activity |
| positive regulation of muscle atrophy |
| initiation of primordial ovarian follicle growth |
| cellular response to corticosterone stimulus |
| regulation of muscle atrophy |
| positive regulation of hydrogen peroxide-mediated programmed cell death |
| response to water-immersion restraint stress |
| positive regulation of hydrogen peroxide-induced cell death |
| cellular response to mineralocorticoid stimulus |
| transcription cofactor binding |
| positive regulation of muscle adaptation |
| antral ovarian follicle growth |
| positive regulation of response to reactive oxygen species |
| regulation of hydrogen peroxide-mediated programmed cell death |
| ovulation from ovarian follicle |
| positive regulation of cellular response to drug |
| mitochondrial transcription |
| positive regulation of oxidative stress-induced cell death |
| positive regulation of cellular response to oxidative stress |
| ovulation |
| positive regulation of endothelial cell apoptotic process |
| positive regulation of response to oxidative stress |
| oocyte maturation |
| response to corticosterone |
| regulation of hydrogen peroxide-induced cell death |
| neuronal stem cell population maintenance |
| response to immobilization stress |
| positive regulation of erythrocyte differentiation |
| signal transduction in absence of ligand |
| positive regulation of response to drug |
| extrinsic apoptotic signaling pathway in absence of ligand |
| positive regulation of epithelial cell apoptotic process |
| response to mineralocorticoid |
| brain morphogenesis |
| regulation of response to reactive oxygen species |
| regulation of cellular response to drug |
| oocyte development |
| cellular response to amyloid-beta |
| mitochondrial RNA metabolic process |
| response to dexamethasone |
| ovulation cycle process |
| oocyte differentiation |
| regulation of erythrocyte differentiation |
| response to amyloid-beta |
| cellular response to nerve growth factor stimulus |
| regulation of endothelial cell apoptotic process |
| positive regulation of reactive oxygen species biosynthetic process |
| ovarian follicle development |
| response to nerve growth factor |
| positive regulation of neuron apoptotic process |
| cellular response to glucocorticoid stimulus |
| cellular response to corticosteroid stimulus |
| regulation of oxidative stress-induced cell death |
| ovulation cycle |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| chromatin DNA binding |
| cellular response to monosaccharide stimulus |
| regulation of cellular response to oxidative stress |
| oogenesis |
| regulation of epithelial cell apoptotic process |
| DNA damage response, signal transduction by p53 class mediator |
| cellular response to carbohydrate stimulus |
| beta-catenin binding |
| cellular response to alcohol |
| regulation of response to oxidative stress |
| regulation of muscle adaptation |
| regulation of reactive oxygen species biosynthetic process |
| cellular glucose homeostasis |
| insulin receptor signaling pathway |
| regulation of neural precursor cell proliferation |
| female gonad development |
| positive regulation of neuron death |
| cellular response to ketone |
| positive regulation of myeloid cell differentiation |
| development of primary female sexual characteristics |
| response to antineoplastic agent |
| positive regulation of reactive oxygen species metabolic process |
| extrinsic apoptotic signaling pathway |
| regulation of response to drug |
| signal transduction in response to DNA damage |
| female sex differentiation |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of autophagy |
| signal transduction by p53 class mediator |
| female gamete generation |
| anatomical structure maturation |
| stem cell population maintenance |
| maintenance of cell number |
| response to glucose |
| mitochondrial gene expression |
| response to hexose |
| response to glucocorticoid |
| response to monosaccharide |
| cell maturation |
| response to corticosteroid |
| mitochondrial outer membrane |
| cellular response to insulin stimulus |
| response to carbohydrate |
| negative regulation of canonical Wnt signaling pathway |
| regulation of reactive oxygen species metabolic process |
| glucose homeostasis |
| carbohydrate homeostasis |
| cellular response to hypoxia |
| positive regulation of hemopoiesis |
| cellular response to steroid hormone stimulus |
| response to starvation |
| response to ketone |
| cellular response to decreased oxygen levels |
| regulation of neuron apoptotic process |
| gonad development |
| negative regulation of Wnt signaling pathway |
| cellular response to oxygen levels |
| development of primary sexual characteristics |
| regulation of myeloid cell differentiation |
| negative regulation of neuron differentiation |
| response to insulin |
| response to alcohol |
| regulation of muscle system process |
| cellular response to tumor necrosis factor |
| developmental maturation |
| cellular response to oxidative stress |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| germ cell development |
| negative regulation of cell migration |
| response to tumor necrosis factor |
| sex differentiation |
| cellular response to peptide hormone stimulus |
| negative regulation of cell motility |
| rhythmic process |
| aging |
| regulation of canonical Wnt signaling pathway |
| apoptotic signaling pathway |
| negative regulation of neurogenesis |
| response to xenobiotic stimulus |
| negative regulation of cellular component movement |
| regulation of neuron death |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| cellular response to peptide |
| response to steroid hormone |
| regulation of autophagy |
| transcription factor binding |
| negative regulation of cell development |
| response to hypoxia |
| regulation of translation |
| cellular process involved in reproduction in multicellular organism |
| response to decreased oxygen levels |
| regulation of Wnt signaling pathway |
| positive regulation of cellular catabolic process |
| mitochondrial matrix |
| response to oxygen levels |
| response to oxidative stress |
| developmental growth |
| response to peptide hormone |
| growth |
| regulation of cellular amide metabolic process |
| sequence-specific DNA binding |
| reproductive structure development |
| reproductive system development |
| positive regulation of catabolic process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of hemopoiesis |
| protein kinase binding |
| response to peptide |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular response to lipid |
| posttranscriptional regulation of gene expression |
| response to extracellular stimulus |
| response to growth factor |
| cellular response to organic cyclic compound |
| regulation of system process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| RNA biosynthetic process |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| DNA-binding transcription factor activity |
| gamete generation |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| brain development |
| cellular chemical homeostasis |
| cellular response to DNA damage stimulus |
| head development |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| regulation of catabolic process |
| multi-organism reproductive process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| programmed cell death |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell death |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| chemical homeostasis |
| positive regulation of immune system process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| VER-155008 3.9μM R06 exp301 | 1.74 |
| Ribavirin 10 to 15μM on day4 R04 exp160 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15846
- Expression level (log2 read counts): 5.36
Expression Distribution
FOXO3 Expression in NALM6 Cells: 5.36
