FPR2 [The Human Chemical-Genetic Interaction Map Project]

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======= FPR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FPR2
  * **<color #00a2e8>Official Name</color>**: formyl peptide receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2358|2358]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25090|P25090]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FPR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FPR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of 1-phosphatidylinositol-3-kinase activity|
|regulation of 1-phosphatidylinositol-3-kinase activity|
|scavenger receptor binding|
|N-formyl peptide receptor activity|
|positive regulation of phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol biosynthetic process|
|positive regulation of phospholipid biosynthetic process|
|complement receptor mediated signaling pathway|
|cargo receptor activity|
|regulation of phospholipid biosynthetic process|
|positive regulation of monocyte chemotaxis|
|positive regulation of superoxide anion generation|
|astrocyte activation|
|regulation of superoxide anion generation|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|positive regulation of phosphatidylinositol 3-kinase activity|
|regulation of superoxide metabolic process|
|positive regulation of lipid kinase activity|
|astrocyte development|
|glial cell activation|
|cellular response to amyloid-beta|
|neuroinflammatory response|
|regulation of mononuclear cell migration|
|positive chemotaxis|
|positive regulation of phospholipid metabolic process|
|response to amyloid-beta|
|macrophage activation|
|regulation of phosphatidylinositol 3-kinase activity|
|astrocyte differentiation|
|ficolin-1-rich granule membrane|
|regulation of lipid kinase activity|
|positive regulation of phagocytosis|
|tertiary granule membrane|
|positive regulation of lipid biosynthetic process|
|amyloid-beta binding|
|regulation of phospholipid metabolic process|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|positive regulation of leukocyte chemotaxis|
|specific granule membrane|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of phagocytosis|
|positive regulation of reactive oxygen species metabolic process|
|glial cell development|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|negative regulation of inflammatory response|
|positive regulation of lipid metabolic process|
|calcium-mediated signaling|
|glial cell differentiation|
|regulation of reactive oxygen species metabolic process|
|regulation of lipid biosynthetic process|
|regulation of leukocyte migration|
|signaling receptor activity|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|defense response to bacterium|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|regulation of lipid metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|endocytosis|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|import into cell|
|response to bacterium|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|ion homeostasis|
|exocytosis|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.06|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.79|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.8|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4955
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FPR2 Expression in NALM6 Cells: -1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>