FPR2
Gene Information
- Official Symbol: FPR2
- Official Name: formyl peptide receptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2358
- UniProt: P25090
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| positive regulation of 1-phosphatidylinositol-3-kinase activity |
| regulation of 1-phosphatidylinositol-3-kinase activity |
| scavenger receptor binding |
| N-formyl peptide receptor activity |
| positive regulation of phosphatidylinositol biosynthetic process |
| regulation of phosphatidylinositol biosynthetic process |
| positive regulation of phospholipid biosynthetic process |
| complement receptor mediated signaling pathway |
| cargo receptor activity |
| regulation of phospholipid biosynthetic process |
| positive regulation of monocyte chemotaxis |
| positive regulation of superoxide anion generation |
| astrocyte activation |
| regulation of superoxide anion generation |
| positive regulation of mononuclear cell migration |
| regulation of monocyte chemotaxis |
| microglial cell activation |
| leukocyte activation involved in inflammatory response |
| positive regulation of phosphatidylinositol 3-kinase activity |
| regulation of superoxide metabolic process |
| positive regulation of lipid kinase activity |
| astrocyte development |
| glial cell activation |
| cellular response to amyloid-beta |
| neuroinflammatory response |
| regulation of mononuclear cell migration |
| positive chemotaxis |
| positive regulation of phospholipid metabolic process |
| response to amyloid-beta |
| macrophage activation |
| regulation of phosphatidylinositol 3-kinase activity |
| astrocyte differentiation |
| ficolin-1-rich granule membrane |
| regulation of lipid kinase activity |
| positive regulation of phagocytosis |
| tertiary granule membrane |
| positive regulation of lipid biosynthetic process |
| amyloid-beta binding |
| regulation of phospholipid metabolic process |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| positive regulation of leukocyte chemotaxis |
| specific granule membrane |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of phagocytosis |
| positive regulation of reactive oxygen species metabolic process |
| glial cell development |
| regulation of leukocyte chemotaxis |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| negative regulation of inflammatory response |
| positive regulation of lipid metabolic process |
| calcium-mediated signaling |
| glial cell differentiation |
| regulation of reactive oxygen species metabolic process |
| regulation of lipid biosynthetic process |
| regulation of leukocyte migration |
| signaling receptor activity |
| negative regulation of defense response |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| gliogenesis |
| receptor-mediated endocytosis |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| defense response to bacterium |
| regulation of inflammatory response |
| second-messenger-mediated signaling |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| regulation of lipid metabolic process |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| neutrophil degranulation |
| divalent inorganic cation homeostasis |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| inflammatory response |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| endocytosis |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| leukocyte activation involved in immune response |
| metal ion homeostasis |
| cell activation involved in immune response |
| activation of immune response |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| import into cell |
| response to bacterium |
| regulated exocytosis |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| ion homeostasis |
| exocytosis |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cell motility |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| response to organonitrogen compound |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| chemical homeostasis |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ1 0.06μM R08 exp531 | -2.06 |
| Dimethyl-Sulfoxide 1pc R03 exp120 | -1.79 |
| THZ531 0.11μM R07 exp409 | 1.8 |
| Trientine 500μM R08 exp534 | 2.15 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4955
- Expression level (log2 read counts): -1.24
Expression Distribution
FPR2 Expression in NALM6 Cells: -1.24
