FPR3

Entrez Summary: N/A
UniProt Summary: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-formyl peptide receptor activity
complement receptor mediated signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
immune response-activating cell surface receptor signaling pathway
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
immune response-regulating cell surface receptor signaling pathway
divalent inorganic cation homeostasis
inflammatory response
chemotaxis
taxis
cellular metal ion homeostasis
immune response-activating signal transduction
immune response-regulating signaling pathway
metal ion homeostasis
activation of immune response
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
positive regulation of immune response
cellular homeostasis
chemical homeostasis
regulation of immune response
positive regulation of immune system process
locomotion
G protein-coupled receptor signaling pathway
defense response
homeostatic process
regulation of immune system process