FRAT1

Entrez Summary: N/A
UniProt Summary: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:12556519}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 1μM R00 exp29	-1.88
CVT-10216 0.1μM R06 exp278	1.74

beta-catenin destruction complex disassembly
canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
protein-containing complex disassembly
regulation of canonical Wnt signaling pathway
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cellular component disassembly
cell surface receptor signaling pathway involved in cell-cell signaling
intracellular membrane-bounded organelle
cell-cell signaling
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
protein-containing complex subunit organization