FRK

Entrez Summary: N/A
UniProt Summary: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BAY-598 4μM R05 exp220	-1.91
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.76

peptidyl-tyrosine autophosphorylation
non-membrane spanning protein tyrosine kinase activity
extrinsic component of cytoplasmic side of plasma membrane
specific granule lumen
intracellular
protein tyrosine kinase activity
azurophil granule lumen
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
protein autophosphorylation
signaling receptor binding
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
transmembrane receptor protein tyrosine kinase signaling pathway
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
negative regulation of cell population proliferation
regulated exocytosis
enzyme linked receptor protein signaling pathway
leukocyte mediated immunity
exocytosis
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
leukocyte activation
protein phosphorylation
secretion by cell
export from cell
cell activation
immune effector process
secretion
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process