FRMD7

Gene Information

Official Symbol: FRMD7
Official Name: FERM domain containing 7
Aliases and Previous Symbols: N/A
Entrez ID: 90167
UniProt: Q6ZUT3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Mutations in this gene are associated with X-linked congenital nystagmus. [provided by RefSeq, Dec 2008].
UniProt Summary: Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. {ECO:0000250|UniProtKB:A2AD83, ECO:0000269|PubMed:17013395, ECO:0000269|PubMed:23946638}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18158
Expression level (log2 read counts): -4.01

Expression Distribution

FA
FERM C
FERM M
FERM N

Rac guanyl-nucleotide exchange factor activity
positive regulation of lamellipodium assembly
negative regulation of stress fiber assembly
negative regulation of actin filament bundle assembly
positive regulation of lamellipodium organization
regulation of lamellipodium assembly
regulation of lamellipodium organization
positive regulation of small GTPase mediated signal transduction
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
positive regulation of plasma membrane bounded cell projection assembly
negative regulation of protein binding
growth cone
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
negative regulation of binding
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of protein binding
regulation of actin filament organization
neuron projection
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
cytoskeleton
neuronal cell body
negative regulation of organelle organization
regulation of binding
positive regulation of cell projection organization
regulation of actin filament-based process
regulation of neuron projection development
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
molecular function
regulation of neurogenesis