FRYL [The Human Chemical-Genetic Interaction Map Project]

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======= FRYL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FRYL
  * **<color #00a2e8>Official Name</color>**: FRY like transcription coactivator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285527|285527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94915|O94915]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FRYL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FRYL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620798|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell cortex|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.02|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.84|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.71|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.79|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.87|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5094
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FRYL Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>