FRYL

Entrez Summary: N/A
UniProt Summary: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pomalidomide 20μM R07 exp391	-2.02
MLN-4924 0.2μM R00 exp21	-1.84
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.71
Colchicine 0.009μM R05 exp215	1.79
Nicotinamide Riboside 100μM R03 exp139	1.79
AICAR 240μM R05 exp211	1.87
Mdivi-1 15μM R05 exp217	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell cortex
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
generation of neurons
neurogenesis
cell development