FRZB

Entrez Summary: The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010].
UniProt Summary: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-1.72
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.72
Mubritinib 0.2μM R01 exp48	1.78
YM155 0.0002μM R01 exp61	1.83
NFN1 0.1μM R01 exp49	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Fz
NTR

negative regulation of hepatocyte differentiation
regulation of hepatocyte differentiation
convergent extension involved in organogenesis
convergent extension
cochlea morphogenesis
negative regulation of cartilage development
Wnt-protein binding
negative regulation of epithelial cell differentiation
cochlea development
positive regulation of fat cell differentiation
regulation of cartilage development
somite development
neural crest cell differentiation
canonical Wnt signaling pathway
inner ear morphogenesis
ear morphogenesis
regulation of fat cell differentiation
non-canonical Wnt signaling pathway
regulation of epithelial cell differentiation
mesenchymal cell differentiation
stem cell differentiation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell growth
inner ear development
negative regulation of Wnt signaling pathway
mesenchyme development
ear development
negative regulation of growth
sensory organ morphogenesis
regulation of canonical Wnt signaling pathway
embryonic organ morphogenesis
negative regulation of cell development
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
regulation of cell growth
cell surface receptor signaling pathway involved in cell-cell signaling
morphogenesis of an epithelium
embryonic organ development
skeletal system development