FSHB [The Human Chemical-Genetic Interaction Map Project]

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======= FSHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FSHB
  * **<color #00a2e8>Official Name</color>**: follicle stimulating hormone subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2488|2488]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01225|P01225]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FSHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FSHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates development of follicle and spermatogenesis in the reproductive organs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cys knot|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|follicle-stimulating hormone activity|
|follicle-stimulating hormone complex|
|progesterone biosynthetic process|
|Sertoli cell proliferation|
|follicle-stimulating hormone signaling pathway|
|progesterone metabolic process|
|C21-steroid hormone biosynthetic process|
|positive regulation of steroid biosynthetic process|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|positive regulation of steroid metabolic process|
|C21-steroid hormone metabolic process|
|ketone biosynthetic process|
|positive regulation of tissue remodeling|
|peptide hormone processing|
|regulation of bone resorption|
|ovulation cycle process|
|steroid hormone biosynthetic process|
|regulation of bone remodeling|
|ovarian follicle development|
|hormone biosynthetic process|
|regulation of osteoclast differentiation|
|ovulation cycle|
|cellular ketone metabolic process|
|regulation of tissue remodeling|
|positive regulation of lipid biosynthetic process|
|epithelial cell proliferation|
|regulation of steroid biosynthetic process|
|female gonad development|
|development of primary female sexual characteristics|
|hormone activity|
|transforming growth factor beta receptor signaling pathway|
|female sex differentiation|
|regulation of steroid metabolic process|
|regulation of myeloid leukocyte differentiation|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|female gamete generation|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of lipid metabolic process|
|cellular response to transforming growth factor beta stimulus|
|male sex differentiation|
|protein processing|
|response to transforming growth factor beta|
|hormone-mediated signaling pathway|
|regulation of signaling receptor activity|
|female pregnancy|
|regulation of lipid biosynthetic process|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|hormone metabolic process|
|gonad development|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|regulation of myeloid cell differentiation|
|protein maturation|
|steroid metabolic process|
|sex differentiation|
|regulation of leukocyte differentiation|
|rhythmic process|
|cellular process involved in reproduction in multicellular organism|
|regulation of lipid metabolic process|
|reproductive structure development|
|reproductive system development|
|regulation of hemopoiesis|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|drug metabolic process|
|positive regulation of cell motility|
|peptide metabolic process|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell population proliferation|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|proteolysis|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FSHB Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>