FSHB

Entrez Summary: The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Stimulates development of follicle and spermatogenesis in the reproductive organs.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

follicle-stimulating hormone activity
follicle-stimulating hormone complex
progesterone biosynthetic process
Sertoli cell proliferation
follicle-stimulating hormone signaling pathway
progesterone metabolic process
C21-steroid hormone biosynthetic process
positive regulation of steroid biosynthetic process
positive regulation of bone resorption
positive regulation of bone remodeling
positive regulation of steroid metabolic process
C21-steroid hormone metabolic process
ketone biosynthetic process
positive regulation of tissue remodeling
peptide hormone processing
regulation of bone resorption
ovulation cycle process
steroid hormone biosynthetic process
regulation of bone remodeling
ovarian follicle development
hormone biosynthetic process
regulation of osteoclast differentiation
ovulation cycle
cellular ketone metabolic process
regulation of tissue remodeling
positive regulation of lipid biosynthetic process
epithelial cell proliferation
regulation of steroid biosynthetic process
female gonad development
development of primary female sexual characteristics
hormone activity
transforming growth factor beta receptor signaling pathway
female sex differentiation
regulation of steroid metabolic process
regulation of myeloid leukocyte differentiation
cellular hormone metabolic process
steroid biosynthetic process
female gamete generation
male gonad development
development of primary male sexual characteristics