FSHR [The Human Chemical-Genetic Interaction Map Project]

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======= FSHR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FSHR
  * **<color #00a2e8>Official Name</color>**: follicle stimulating hormone receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2492|2492]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23945|P23945]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FSHR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FSHR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|LRRNT|
|GnHR trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|follicle-stimulating hormone receptor activity|
|follicle-stimulating hormone signaling pathway|
|cellular response to follicle-stimulating hormone stimulus|
|response to follicle-stimulating hormone|
|cellular response to gonadotropin stimulus|
|regulation of protein kinase A signaling|
|response to gonadotropin|
|G protein-coupled peptide receptor activity|
|activation of adenylate cyclase activity|
|ovulation cycle process|
|ovarian follicle development|
|ovulation cycle|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|female gamete generation|
|male gonad development|
|development of primary male sexual characteristics|
|cAMP-mediated signaling|
|male sex differentiation|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|development of primary sexual characteristics|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|sex differentiation|
|rhythmic process|
|regulation of ERK1 and ERK2 cascade|
|second-messenger-mediated signaling|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|reproductive system development|
|positive regulation of MAPK cascade|
|spermatogenesis|
|male gamete generation|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|gamete generation|
|regulation of MAPK cascade|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to hormone|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14271
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FSHR Expression in NALM6 Cells: -1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>