FSHR

Gene Information

Official Symbol: FSHR
Official Name: follicle stimulating hormone receptor
Aliases and Previous Symbols: N/A
Entrez ID: 2492
UniProt: P23945
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14271
Expression level (log2 read counts): -1.52

Expression Distribution

7tm 1
LRRNT
GnHR trans

follicle-stimulating hormone receptor activity
follicle-stimulating hormone signaling pathway
cellular response to follicle-stimulating hormone stimulus
response to follicle-stimulating hormone
cellular response to gonadotropin stimulus
regulation of protein kinase A signaling
response to gonadotropin
G protein-coupled peptide receptor activity
activation of adenylate cyclase activity
ovulation cycle process
ovarian follicle development
ovulation cycle
positive regulation of phosphatidylinositol 3-kinase signaling
female gonad development
development of primary female sexual characteristics
female sex differentiation
regulation of phosphatidylinositol 3-kinase signaling
adenylate cyclase-activating G protein-coupled receptor signaling pathway
female gamete generation
male gonad development
development of primary male sexual characteristics
cAMP-mediated signaling
male sex differentiation
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
receptor complex
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
gonad development
positive regulation of ERK1 and ERK2 cascade
development of primary sexual characteristics
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sex differentiation
rhythmic process
regulation of ERK1 and ERK2 cascade
second-messenger-mediated signaling
cellular process involved in reproduction in multicellular organism
reproductive structure development
reproductive system development
positive regulation of MAPK cascade
spermatogenesis