FST

Gene Information

Official Symbol: FST
Official Name: follistatin
Aliases and Previous Symbols: N/A
Entrez ID: 10468
UniProt: P19883
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14783
Expression level (log2 read counts): -0.19

Expression Distribution

Kazal 2
FOLN
Kazal 1

activin receptor antagonist activity
negative regulation of activin receptor signaling pathway
positive regulation of hair follicle development
positive regulation of hair cycle
activin binding
heparan sulfate proteoglycan binding
regulation of hair follicle development
regulation of activin receptor signaling pathway
regulation of hair cycle
positive regulation of epidermis development
regulation of epidermis development
hematopoietic progenitor cell differentiation
regulation of BMP signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
extracellular space
negative regulation of response to stimulus
negative regulation of gene expression
positive regulation of multicellular organismal process
extracellular region