FTCD

Entrez Summary: The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009].
UniProt Summary: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutamate formimidoyltransferase activity
formimidoyltetrahydrofolate cyclodeaminase activity
formimidoyltransferase activity
formamide metabolic process
histidine catabolic process to glutamate and formate
histidine catabolic process to glutamate and formamide
formate metabolic process
smooth endoplasmic reticulum membrane
imidazole-containing compound catabolic process
histidine catabolic process
histidine metabolic process
tetrahydrofolate interconversion
folic acid binding
imidazole-containing compound metabolic process
tetrahydrofolate metabolic process
one-carbon metabolic process
aromatic amino acid family catabolic process
folic acid-containing compound metabolic process
glutamate metabolic process
pteridine-containing compound metabolic process
aromatic amino acid family metabolic process
glutamine family amino acid metabolic process
endoplasmic reticulum-Golgi intermediate compartment
dicarboxylic acid metabolic process
antibiotic metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
centriole
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
microtubule binding
coenzyme metabolic process
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
cofactor metabolic process
aromatic compound catabolic process