FUT7 [The Human Chemical-Genetic Interaction Map Project]

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======= FUT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FUT7
  * **<color #00a2e8>Official Name</color>**: fucosyltransferase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2529|2529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q11130|Q11130]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FUT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FUT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens. {ECO:0000269|PubMed:11404359, ECO:0000269|PubMed:8207002, ECO:0000269|PubMed:9299472}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukocyte migration involved in immune response|
|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|regulatory T cell differentiation|
|alpha-(1->3)-fucosyltransferase activity|
|fucosyltransferase activity|
|L-fucose catabolic process|
|fucose catabolic process|
|L-fucose metabolic process|
|fucose metabolic process|
|fucosylation|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell differentiation|
|hexose catabolic process|
|alpha-beta T cell activation|
|monosaccharide catabolic process|
|ceramide metabolic process|
|Golgi cisterna membrane|
|carbohydrate catabolic process|
|T cell differentiation|
|sphingolipid metabolic process|
|hexose metabolic process|
|monosaccharide metabolic process|
|membrane lipid metabolic process|
|T cell activation|
|lymphocyte differentiation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|leukocyte differentiation|
|leukocyte migration|
|lymphocyte activation|
|glycoprotein metabolic process|
|small molecule catabolic process|
|carbohydrate metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|immune system development|
|cellular amide metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|cell migration|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|lipid metabolic process|
|locomotion|
|organonitrogen compound biosynthetic process|
|movement of cell or subcellular component|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5570
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FUT7 Expression in NALM6 Cells: -1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>