FXYD1

Entrez Summary: N/A
UniProt Summary: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of protein glutathionylation
negative regulation of protein glutathionylation
regulation of sodium ion export across plasma membrane
positive regulation of sodium ion export across plasma membrane
regulation of cardiac muscle cell membrane potential
ion channel regulator activity
sodium:potassium-exchanging ATPase complex
positive regulation of sodium ion transmembrane transport
positive regulation of sodium ion transport
sodium channel regulator activity
T-tubule
intercalated disc
regulation of sodium ion transmembrane transporter activity
chloride channel activity
regulation of sodium ion transmembrane transport
regulation of cardiac conduction
caveola
regulation of sodium ion transport
chloride transmembrane transport
sarcolemma
chloride transport
inorganic anion transmembrane transport
ion channel binding
positive regulation of cation transmembrane transport
sodium ion transport
positive regulation of ion transmembrane transport
inorganic anion transport
potassium ion transport
positive regulation of transmembrane transport
regulation of heart contraction
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
anion transmembrane transport
regulation of transporter activity
regulation of blood circulation
muscle system process
apical plasma membrane
regulation of cation transmembrane transport