FZD5 [The Human Chemical-Genetic Interaction Map Project]

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======= FZD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD5
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7855|7855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13467|Q13467]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). {ECO:0000250|UniProtKB:Q9EQD0, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:20530549, ECO:0000269|PubMed:9054360, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Frizzled|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|
|Spemann organizer formation|
|chorionic trophoblast cell differentiation|
|regulation of chorionic trophoblast cell proliferation|
|chorion development|
|post-embryonic camera-type eye development|
|extraembryonic membrane development|
|branching involved in labyrinthine layer morphogenesis|
|tripartite regional subdivision|
|anterior/posterior axis specification, embryo|
|post-embryonic animal organ development|
|apoptotic process involved in morphogenesis|
|Wnt-activated receptor activity|
|blastoderm segmentation|
|positive regulation of T cell cytokine production|
|labyrinthine layer blood vessel development|
|positive regulation of tumor necrosis factor secretion|
|beta-catenin destruction complex disassembly|
|regulation of bicellular tight junction assembly|
|labyrinthine layer morphogenesis|
|cell differentiation involved in embryonic placenta development|
|embryonic placenta morphogenesis|
|embryonic camera-type eye morphogenesis|
|developmental induction|
|apoptotic process involved in development|
|regulation of tumor necrosis factor secretion|
|placenta blood vessel development|
|regulation of T cell cytokine production|
|positive regulation of protein targeting to mitochondrion|
|clathrin-coated endocytic vesicle membrane|
|positive regulation of interleukin-1 beta secretion|
|embryonic eye morphogenesis|
|embryonic axis specification|
|embryonic camera-type eye development|
|Wnt signaling pathway, calcium modulating pathway|
|Wnt-protein binding|
|positive regulation of interleukin-1 secretion|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|labyrinthine layer development|
|regulation of interleukin-1 beta secretion|
|T cell differentiation in thymus|
|positive regulation of T cell mediated immunity|
|anterior/posterior axis specification|
|positive regulation of interleukin-1 beta production|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-1 secretion|
|positive regulation of establishment of protein localization to mitochondrion|
|positive regulation of interleukin-1 production|
|embryonic pattern specification|
|positive regulation of interferon-gamma production|
|regulation of T cell mediated immunity|
|positive regulation of JUN kinase activity|
|regulation of establishment of protein localization to mitochondrion|
|amyloid-beta binding|
|regulation of interleukin-1 beta production|
|regulation of protein targeting|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|axis specification|
|regulation of JUN kinase activity|
|embryonic placenta development|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|post-embryonic development|
|regulation of cell junction assembly|
|canonical Wnt signaling pathway|
|synapse assembly|
|regulation of interleukin-1 production|
|segmentation|
|Wnt signaling pathway, planar cell polarity pathway|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of establishment of planar polarity|
|camera-type eye morphogenesis|
|positive regulation of mitochondrion organization|
|bicellular tight junction|
|positive regulation of leukocyte mediated immunity|
|perikaryon|
|non-canonical Wnt signaling pathway|
|T cell differentiation|
|positive regulation of JNK cascade|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|eye morphogenesis|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|placenta development|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of intracellular protein transport|
|lipid binding|
|cell maturation|
|morphogenesis of a branching epithelium|
|regulation of adaptive immune response|
|positive regulation of stress-activated MAPK cascade|
|morphogenesis of a branching structure|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of mitochondrion organization|
|regulation of morphogenesis of an epithelium|
|regulation of JNK cascade|
|cellular response to molecule of bacterial origin|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|cellular response to biotic stimulus|
|anterior/posterior pattern specification|
|positive regulation of immune effector process|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|developmental maturation|
|protein-containing complex disassembly|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|synapse|
|synapse organization|
|positive regulation of protein secretion|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|ubiquitin protein ligase binding|
|axon|
|camera-type eye development|
|angiogenesis|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|regulation of autophagy|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of intracellular transport|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|lymphocyte activation|
|cellular component disassembly|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|dendrite|
|positive regulation of protein transport|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|pattern specification process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|blood vessel development|
|regulation of peptide secretion|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|sensory organ development|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|hematopoietic or lymphoid organ development|
|cell surface|
|Golgi membrane|
|positive regulation of organelle organization|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|embryo development|
|positive regulation of transport|
|regulation of catabolic process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell death|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17541
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD5 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>