FZD5
Gene Information
- Official Symbol: FZD5
- Official Name: frizzled class receptor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 7855
- UniProt: Q13467
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008].
- UniProt Summary: Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). {ECO:0000250|UniProtKB:Q9EQD0, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:20530549, ECO:0000269|PubMed:9054360, ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| Frizzled |
| Fz |
GO Terms
| syncytiotrophoblast cell differentiation involved in labyrinthine layer development |
| Spemann organizer formation |
| chorionic trophoblast cell differentiation |
| regulation of chorionic trophoblast cell proliferation |
| chorion development |
| post-embryonic camera-type eye development |
| extraembryonic membrane development |
| branching involved in labyrinthine layer morphogenesis |
| tripartite regional subdivision |
| anterior/posterior axis specification, embryo |
| post-embryonic animal organ development |
| apoptotic process involved in morphogenesis |
| Wnt-activated receptor activity |
| blastoderm segmentation |
| positive regulation of T cell cytokine production |
| labyrinthine layer blood vessel development |
| positive regulation of tumor necrosis factor secretion |
| beta-catenin destruction complex disassembly |
| regulation of bicellular tight junction assembly |
| labyrinthine layer morphogenesis |
| cell differentiation involved in embryonic placenta development |
| embryonic placenta morphogenesis |
| embryonic camera-type eye morphogenesis |
| developmental induction |
| apoptotic process involved in development |
| regulation of tumor necrosis factor secretion |
| placenta blood vessel development |
| regulation of T cell cytokine production |
| positive regulation of protein targeting to mitochondrion |
| clathrin-coated endocytic vesicle membrane |
| positive regulation of interleukin-1 beta secretion |
| embryonic eye morphogenesis |
| embryonic axis specification |
| embryonic camera-type eye development |
| Wnt signaling pathway, calcium modulating pathway |
| Wnt-protein binding |
| positive regulation of interleukin-1 secretion |
| regulation of autophagy of mitochondrion |
| regulation of protein targeting to mitochondrion |
| labyrinthine layer development |
| regulation of interleukin-1 beta secretion |
| T cell differentiation in thymus |
| positive regulation of T cell mediated immunity |
| anterior/posterior axis specification |
| positive regulation of interleukin-1 beta production |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-1 secretion |
| positive regulation of establishment of protein localization to mitochondrion |
| positive regulation of interleukin-1 production |
| embryonic pattern specification |
| positive regulation of interferon-gamma production |
| regulation of T cell mediated immunity |
| positive regulation of JUN kinase activity |
| regulation of establishment of protein localization to mitochondrion |
| amyloid-beta binding |
| regulation of interleukin-1 beta production |
| regulation of protein targeting |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| axis specification |
| regulation of JUN kinase activity |
| embryonic placenta development |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| post-embryonic development |
| regulation of cell junction assembly |
| canonical Wnt signaling pathway |
| synapse assembly |
| regulation of interleukin-1 production |
| segmentation |
| Wnt signaling pathway, planar cell polarity pathway |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| regulation of establishment of planar polarity |
| camera-type eye morphogenesis |
| positive regulation of mitochondrion organization |
| bicellular tight junction |
| positive regulation of leukocyte mediated immunity |
| perikaryon |
| non-canonical Wnt signaling pathway |
| T cell differentiation |
| positive regulation of JNK cascade |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| eye morphogenesis |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| early endosome membrane |
| placenta development |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of intracellular protein transport |
| lipid binding |
| cell maturation |
| morphogenesis of a branching epithelium |
| regulation of adaptive immune response |
| positive regulation of stress-activated MAPK cascade |
| morphogenesis of a branching structure |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of mitochondrion organization |
| regulation of morphogenesis of an epithelium |
| regulation of JNK cascade |
| cellular response to molecule of bacterial origin |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| cellular response to biotic stimulus |
| anterior/posterior pattern specification |
| positive regulation of immune effector process |
| regulation of intracellular protein transport |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| developmental maturation |
| protein-containing complex disassembly |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of MAP kinase activity |
| protein-containing complex binding |
| synapse |
| synapse organization |
| positive regulation of protein secretion |
| embryonic organ morphogenesis |
| positive regulation of peptide secretion |
| ubiquitin protein ligase binding |
| axon |
| camera-type eye development |
| angiogenesis |
| positive regulation of cellular protein localization |
| response to molecule of bacterial origin |
| leukocyte differentiation |
| regulation of autophagy |
| regionalization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of intracellular transport |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| eye development |
| visual system development |
| sensory system development |
| in utero embryonic development |
| lymphocyte activation |
| cellular component disassembly |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| dendrite |
| positive regulation of protein transport |
| reproductive structure development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| positive regulation of secretion |
| pattern specification process |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| regulation of immune effector process |
| blood vessel development |
| regulation of peptide secretion |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of protein kinase activity |
| regulation of cellular protein localization |
| positive regulation of MAPK cascade |
| sensory organ development |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| hematopoietic or lymphoid organ development |
| cell surface |
| Golgi membrane |
| positive regulation of organelle organization |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| response to bacterium |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| G protein-coupled receptor activity |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cellular catabolic process |
| tube development |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| embryo development |
| positive regulation of transport |
| regulation of catabolic process |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| programmed cell death |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| cell death |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| VER-155008 3.9μM R06 exp301 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17541
- Expression level (log2 read counts): 4.53
Expression Distribution
FZD5 Expression in NALM6 Cells: 4.53
