GAB1 [The Human Chemical-Genetic Interaction Map Project]

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======= GAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAB1
  * **<color #00a2e8>Official Name</color>**: GRB2 associated binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2549|2549]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13480|Q13480]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604439|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell chemotaxis to vascular endothelial growth factor|
|cell chemotaxis to vascular endothelial growth factor|
|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|
|response to hepatocyte growth factor|
|vascular endothelial growth factor signaling pathway|
|ERBB2 signaling pathway|
|cellular response to vascular endothelial growth factor stimulus|
|epidermal growth factor receptor signaling pathway|
|SH3/SH2 adaptor activity|
|actin cytoskeleton reorganization|
|ERBB signaling pathway|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|insulin receptor signaling pathway|
|regulation of phosphatidylinositol 3-kinase signaling|
|cellular response to insulin stimulus|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|cell-cell junction|
|positive regulation of vasculature development|
|cell chemotaxis|
|regulation of protein kinase B signaling|
|response to insulin|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|cellular response to peptide|
|axonogenesis|
|response to peptide hormone|
|blood vessel morphogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|tube morphogenesis|
|cellular response to nitrogen compound|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8423
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAB1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>