GAB1

Entrez Summary: N/A
UniProt Summary: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endothelial cell chemotaxis to vascular endothelial growth factor
cell chemotaxis to vascular endothelial growth factor
positive regulation of cell migration by vascular endothelial growth factor signaling pathway
response to hepatocyte growth factor
vascular endothelial growth factor signaling pathway
ERBB2 signaling pathway
cellular response to vascular endothelial growth factor stimulus
epidermal growth factor receptor signaling pathway
SH3/SH2 adaptor activity
actin cytoskeleton reorganization
ERBB signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
insulin receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
cellular response to insulin stimulus
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
cell-cell junction
positive regulation of vasculature development
cell chemotaxis
regulation of protein kinase B signaling
response to insulin
axon guidance
neuron projection guidance
cellular response to peptide hormone stimulus
regulation of angiogenesis
angiogenesis
regulation of vasculature development
cellular response to peptide
axonogenesis
response to peptide hormone
blood vessel morphogenesis
axon development
cell morphogenesis involved in neuron differentiation
response to peptide
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
blood vessel development
cell projection morphogenesis
actin cytoskeleton organization