GABRA2
Gene Information
- Official Symbol: GABRA2
- Official Name: gamma-aminobutyric acid type A receptor subunit alpha2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2555
- UniProt: P47869
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
- UniProt Summary: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17984
- Expression level (log2 read counts): 0.53
GABRA2 Expression in NALM6 Cells: 0.53
