GABRD
Gene Information
- Official Symbol: GABRD
- Official Name: gamma-aminobutyric acid type A receptor subunit delta
- Aliases and Previous Symbols: N/A
- Entrez ID: 2563
- UniProt: O14764
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
- UniProt Summary: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14426
- Expression level (log2 read counts): -3.8
GABRD Expression in NALM6 Cells: -3.8
