GAGE2A [The Human Chemical-Genetic Interaction Map Project]

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======= GAGE2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAGE2A
  * **<color #00a2e8>Official Name</color>**: G antigen 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=729447|729447]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NT46|Q6NT46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAGE2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAGE2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GAGE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.79|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.58|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.25|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.23|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.14|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.12|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.08|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.99|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.98|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.96|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.92|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.88|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.86|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.83|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.83|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.81|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.76|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.75|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.79|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.83|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.96|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.07|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.1|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.3|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.36|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|1/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|1/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|3/20|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6572
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAGE2A Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>