GAP43

Entrez Summary: N/A
UniProt Summary: This protein is associated with nerve growth. It is a major component of the motile “growth cones” that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lysophosphatidic acid binding
axon choice point recognition
growth cone membrane
regulation of postsynaptic specialization assembly
regulation of postsynapse assembly
phosphatidylinositol phosphate binding
filopodium membrane
axon regeneration
protein kinase C-activating G protein-coupled receptor signaling pathway
neuron projection regeneration
regulation of filopodium assembly
neuron recognition
response to axon injury
phosphatidylserine binding
tissue regeneration
GABA-ergic synapse
regulation of postsynapse organization
regulation of synapse assembly
regeneration
glial cell differentiation
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
calmodulin binding
gliogenesis
regulation of synapse organization
regulation of organelle assembly
regulation of synapse structure or activity
cell recognition
cell fate commitment
postsynaptic density
axon guidance
neuron projection guidance
axonogenesis
developmental growth
growth
axon development
cell morphogenesis involved in neuron differentiation
wound healing
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis