GARS [The Human Chemical-Genetic Interaction Map Project]

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======= GARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GARS1
  * **<color #00a2e8>Official Name</color>**: glycyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2617|2617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41250|P41250]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600287|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:28675565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2b|
|WHEP-TRS|
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine-tRNA ligase activity|
|mitochondrial glycyl-tRNA aminoacylation|
|glycyl-tRNA aminoacylation|
|bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity|
|diadenosine polyphosphate biosynthetic process|
|diadenosine tetraphosphate biosynthetic process|
|diadenosine tetraphosphate metabolic process|
|tRNA aminoacylation for mitochondrial protein translation|
|diadenosine polyphosphate metabolic process|
|mitochondrial RNA metabolic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|transferase activity|
|secretory granule|
|mitochondrial translation|
|mitochondrial gene expression|
|protein dimerization activity|
|tRNA metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|axon|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.83|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.83|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.78|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.78|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.88|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.97|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.03|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.22|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.433|
|[[:human genes:d:dap3|DAP3]]|0.425|
|[[:human genes:f:fastkd5|FASTKD5]]|0.415|
|[[:human genes:m:mrps16|MRPS16]]|0.412|
|[[:human genes:m:mrp63|MRP63]]|0.41|
|[[:human genes:t:tars2|TARS2]]|0.408|
|[[:human genes:c:cox16|COX16]]|0.403|
|[[:human genes:s:selrc1|SELRC1]]|0.401|
|[[:human genes:m:mrps5|MRPS5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 559/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|24/28|
|bone|19/26|
|breast|27/33|
|central nervous system|34/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|9/21|
|liver|16/20|
|lung|49/75|
|lymphocyte|11/16|
|ovary|20/26|
|pancreas|19/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|18/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 541
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GARS Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>