GARS

Entrez Summary: N/A
UniProt Summary: Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:28675565}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 559/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	24/28
bone	19/26
breast	27/33
central nervous system	34/56
cervix	3/4
colorectal	14/17
esophagus	10/13
fibroblast	0/1
gastric	13/16
kidney	9/21
liver	16/20
lung	49/75
lymphocyte	11/16
ovary	20/26
pancreas	19/24
peripheral nervous system	14/16
plasma cell	11/15
prostate	1/1
skin	20/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	18/29
uterus	4/5

Expression Distribution

glycine-tRNA ligase activity
mitochondrial glycyl-tRNA aminoacylation
glycyl-tRNA aminoacylation
bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity
diadenosine polyphosphate biosynthetic process
diadenosine tetraphosphate biosynthetic process
diadenosine tetraphosphate metabolic process
tRNA aminoacylation for mitochondrial protein translation
diadenosine polyphosphate metabolic process
mitochondrial RNA metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
transferase activity
secretory granule
mitochondrial translation
mitochondrial gene expression
protein dimerization activity
tRNA metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
axon
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
nucleotide metabolic process
nucleoside phosphate metabolic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
nucleobase-containing compound biosynthetic process