GAS1 [The Human Chemical-Genetic Interaction Map Project]

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======= GAS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAS1
  * **<color #00a2e8>Official Name</color>**: growth arrest specific 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2619|2619]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54826|P54826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Growth arrest-specific 1 plays a role in growth suppression.  GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells.  Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. {ECO:0000269|PubMed:8127893}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ER to Golgi vesicle-mediated transport|
|anchored component of plasma membrane|
|negative regulation of protein maturation|
|negative regulation of protein processing|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of smoothened signaling pathway|
|cell cycle arrest|
|cell fate commitment|
|negative regulation of mitotic cell cycle|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|developmental growth|
|growth|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of vesicle-mediated transport|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of proteolysis|
|regulation of cellular localization|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.2|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.7|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.78|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.01|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAS1 Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>