GAS1

Entrez Summary: Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. {ECO:0000269|PubMed:8127893}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.2μM R01 exp40	-2.2
UM0011500 10μM R05 exp246	-1.7
UM0011500 5μM R05 exp245	1.78
Ibrutinib 1μM R07 exp372	2.01
Docosahexaenoic-acid 50μM R07 exp356	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of ER to Golgi vesicle-mediated transport
anchored component of plasma membrane
negative regulation of protein maturation
negative regulation of protein processing
cellular response to vascular endothelial growth factor stimulus
regulation of protein processing
regulation of protein maturation
regulation of smoothened signaling pathway
cell cycle arrest
cell fate commitment
negative regulation of mitotic cell cycle
regulation of intracellular transport
negative regulation of proteolysis
developmental growth
growth
cellular response to growth factor stimulus
response to growth factor
regulation of vesicle-mediated transport
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of proteolysis
regulation of cellular localization
cell cycle process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
regulation of cell cycle
cell cycle
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
negative regulation of gene expression
regulation of transport