GBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= GBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GBP1
  * **<color #00a2e8>Official Name</color>**: guanylate binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2633|2633]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32455|P32455]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269|PubMed:22106366}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GBP|
|GBP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-2 secretion|
|regulation of interleukin-2 secretion|
|negative regulation of substrate adhesion-dependent cell spreading|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of protein localization to plasma membrane|
|negative regulation of interleukin-2 production|
|negative regulation of protein localization to cell periphery|
|negative regulation of antigen receptor-mediated signaling pathway|
|spectrin binding|
|vesicle membrane|
|negative regulation of protein localization to membrane|
|regulation of T cell receptor signaling pathway|
|cytokine binding|
|Hsp90 protein binding|
|regulation of substrate adhesion-dependent cell spreading|
|regulation of interleukin-2 production|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of cell-substrate adhesion|
|protein localization to vacuole|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of cytokine secretion|
|interferon-gamma-mediated signaling pathway|
|GDP binding|
|regulation of protein localization to plasma membrane|
|regulation of calcium-mediated signaling|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|cellular response to interferon-gamma|
|negative regulation of MAPK cascade|
|cellular response to interleukin-1|
|negative regulation of protein transport|
|response to interferon-gamma|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|defense response to virus|
|response to interleukin-1|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of cell-substrate adhesion|
|actin cytoskeleton|
|negative regulation of secretion|
|cellular response to tumor necrosis factor|
|cytoplasmic vesicle|
|response to tumor necrosis factor|
|actin binding|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|response to virus|
|regulation of ERK1 and ERK2 cascade|
|regulation of cell morphogenesis involved in differentiation|
|GTPase activity|
|negative regulation of cell development|
|protein homooligomerization|
|enzyme binding|
|GTP binding|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|Golgi membrane|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|innate immune response|
|regulation of secretion|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|immune effector process|
|response to cytokine|
|negative regulation of protein metabolic process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17348
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GBP1 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>