GBP1
Gene Information
- Official Symbol: GBP1
- Official Name: guanylate binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2633
- UniProt: P32455
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269|PubMed:22106366}.
Pfam Domains GO Terms
Pfam Domains
| GBP |
| GBP C |
GO Terms
| negative regulation of interleukin-2 secretion |
| regulation of interleukin-2 secretion |
| negative regulation of substrate adhesion-dependent cell spreading |
| negative regulation of T cell receptor signaling pathway |
| negative regulation of protein localization to plasma membrane |
| negative regulation of interleukin-2 production |
| negative regulation of protein localization to cell periphery |
| negative regulation of antigen receptor-mediated signaling pathway |
| spectrin binding |
| vesicle membrane |
| negative regulation of protein localization to membrane |
| regulation of T cell receptor signaling pathway |
| cytokine binding |
| Hsp90 protein binding |
| regulation of substrate adhesion-dependent cell spreading |
| regulation of interleukin-2 production |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of cell-substrate adhesion |
| protein localization to vacuole |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of cytokine secretion |
| interferon-gamma-mediated signaling pathway |
| GDP binding |
| regulation of protein localization to plasma membrane |
| regulation of calcium-mediated signaling |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular protein localization |
| regulation of protein localization to cell periphery |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| cellular response to interferon-gamma |
| negative regulation of MAPK cascade |
| cellular response to interleukin-1 |
| negative regulation of protein transport |
| response to interferon-gamma |
| negative regulation of establishment of protein localization |
| regulation of protein localization to membrane |
| defense response to virus |
| response to interleukin-1 |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of cell-substrate adhesion |
| actin cytoskeleton |
| negative regulation of secretion |
| cellular response to tumor necrosis factor |
| cytoplasmic vesicle |
| response to tumor necrosis factor |
| actin binding |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| response to virus |
| regulation of ERK1 and ERK2 cascade |
| regulation of cell morphogenesis involved in differentiation |
| GTPase activity |
| negative regulation of cell development |
| protein homooligomerization |
| enzyme binding |
| GTP binding |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| protein complex oligomerization |
| regulation of cellular protein localization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| Golgi membrane |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| innate immune response |
| regulation of secretion |
| protein homodimerization activity |
| regulation of cellular localization |
| regulation of cell development |
| negative regulation of developmental process |
| defense response to other organism |
| Golgi apparatus |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| immune effector process |
| response to cytokine |
| negative regulation of protein metabolic process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| protein-containing complex assembly |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | -2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17348
- Expression level (log2 read counts): 4.87
Expression Distribution
GBP1 Expression in NALM6 Cells: 4.87
