GBX2
Gene Information
- Official Symbol: GBX2
- Official Name: gastrulation brain homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2637
- UniProt: P52951
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| rhombomere 2 development |
| midbrain-hindbrain boundary morphogenesis |
| cerebellar granule cell precursor proliferation |
| cell proliferation in external granule layer |
| cell proliferation in hindbrain |
| rhombomere development |
| midbrain-hindbrain boundary development |
| rostrocaudal neural tube patterning |
| thalamus development |
| branching involved in blood vessel morphogenesis |
| forebrain neuron development |
| neural tube patterning |
| RNA polymerase II core promoter sequence-specific DNA binding |
| autonomic nervous system development |
| forebrain neuron differentiation |
| neural crest cell migration |
| RNA polymerase II transcription factor binding |
| forebrain generation of neurons |
| neural precursor cell proliferation |
| diencephalon development |
| neural crest cell development |
| central nervous system neuron development |
| mesenchymal cell development |
| stem cell development |
| neural crest cell differentiation |
| inner ear morphogenesis |
| cerebellum development |
| metencephalon development |
| ear morphogenesis |
| branching morphogenesis of an epithelial tube |
| hindbrain development |
| mesenchymal cell differentiation |
| stem cell differentiation |
| morphogenesis of a branching epithelium |
| neural tube development |
| morphogenesis of a branching structure |
| ameboidal-type cell migration |
| central nervous system neuron differentiation |
| inner ear development |
| anterior/posterior pattern specification |
| ear development |
| mesenchyme development |
| sensory organ morphogenesis |
| axon guidance |
| neuron projection guidance |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| angiogenesis |
| regionalization |
| axonogenesis |
| forebrain development |
| blood vessel morphogenesis |
| axon development |
| morphogenesis of an epithelium |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| vasculature development |
| cell part morphogenesis |
| cardiovascular system development |
| sensory organ development |
| chemotaxis |
| taxis |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| neuron projection development |
| DNA-binding transcription factor activity |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| animal organ morphogenesis |
| cell migration |
| embryo development |
| central nervous system development |
| neuron differentiation |
| cell motility |
| localization of cell |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of transcription by RNA polymerase II |
| locomotion |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN racemic mixture R03 exp93 | -1.83 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.511 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5205
- Expression level (log2 read counts): -5.28
Expression Distribution
GBX2 Expression in NALM6 Cells: -5.28
