GCC2

Entrez Summary: N/A
UniProt Summary: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Filament
GRIP

recycling endosome to Golgi transport
late endosome to Golgi transport
Golgi ribbon formation
protein targeting to lysosome
regulation of protein exit from endoplasmic reticulum
microtubule anchoring
protein localization to Golgi apparatus
Golgi to plasma membrane protein transport
protein targeting to vacuole
protein localization to lysosome
establishment of protein localization to vacuole
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
protein localization to vacuole
vesicle-mediated transport to the plasma membrane
microtubule organizing center organization
retrograde transport, endosome to Golgi
post-Golgi vesicle-mediated transport
lysosomal transport
Golgi organization
vacuolar transport
cytosolic transport
trans-Golgi network
protein localization to plasma membrane
endosomal transport
protein localization to cell periphery
regulation of intracellular protein transport
establishment of protein localization to membrane
regulation of intracellular transport
protein targeting
Golgi vesicle transport
endomembrane system organization
establishment of protein localization to organelle
microtubule cytoskeleton organization
protein localization to membrane
regulation of cellular protein localization
microtubule-based process
regulation of protein transport
protein localization to organelle
regulation of peptide transport