GCNT4

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. {ECO:0000269|PubMed:10753916}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UNC1999 2μM R03 exp155	1.81
Trientine 500μM R08 exp534	2.29

inter-male aggressive behavior
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
aggressive behavior
thyroid hormone metabolic process
O-glycan processing
multi-organism behavior
phenol-containing compound metabolic process
kidney morphogenesis
protein O-linked glycosylation
cellular modified amino acid metabolic process
homeostasis of number of cells
hormone metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
kidney development
renal system development
urogenital system development
glycoprotein biosynthetic process
glycoprotein metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
regulation of hormone levels
tissue morphogenesis
behavior
Golgi membrane
carbohydrate derivative biosynthetic process
animal organ morphogenesis
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
homeostatic process
cellular macromolecule biosynthetic process
tissue development
macromolecule biosynthetic process