GDAP1

Entrez Summary: This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. [provided by RefSeq, Feb 2012].
UniProt Summary: Regulates the mitochondrial network by promoting mitochondrial fission. {ECO:0000269|PubMed:16172208}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GST N
GST C

cellular response to vitamin D
mitochondrial fusion
mitochondrial fission
integral component of mitochondrial outer membrane
cellular response to vitamin
response to vitamin D
protein targeting to mitochondrion
cellular response to nutrient
establishment of protein localization to mitochondrion
protein localization to mitochondrion
response to vitamin
organelle fusion
response to retinoic acid
mitochondrial transport
response to nutrient
cellular response to nutrient levels
cellular response to extracellular stimulus
organelle fission
cellular response to external stimulus
response to acid chemical
protein targeting
establishment of protein localization to organelle
mitochondrion organization
response to nutrient levels
cellular response to lipid
response to extracellular stimulus
cellular response to organic cyclic compound
protein localization to organelle
response to lipid
response to organic cyclic compound
intracellular protein transport
cellular response to oxygen-containing compound
mitochondrion
protein transport
intracellular transport
peptide transport
response to oxygen-containing compound
amide transport
cellular protein localization
cellular macromolecule localization