GDF15
Gene Information
- Official Symbol: GDF15
- Official Name: growth differentiation factor 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 9518
- UniProt: Q99988
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
GO Terms
| negative regulation of growth hormone receptor signaling pathway |
| reduction of food intake in response to dietary excess |
| regulation of growth hormone receptor signaling pathway |
| glial cell-derived neurotrophic factor receptor signaling pathway |
| negative regulation of multicellular organism growth |
| positive regulation of myoblast fusion |
| regulation of myoblast fusion |
| positive regulation of syncytium formation by plasma membrane fusion |
| response to dietary excess |
| regulation of syncytium formation by plasma membrane fusion |
| eating behavior |
| positive regulation of myotube differentiation |
| transforming growth factor beta receptor binding |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| SMAD protein signal transduction |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| regulation of pathway-restricted SMAD protein phosphorylation |
| regulation of multicellular organism growth |
| feeding behavior |
| positive regulation of muscle cell differentiation |
| BMP signaling pathway |
| regulation of striated muscle cell differentiation |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to BMP stimulus |
| response to BMP |
| negative regulation of developmental growth |
| regulation of muscle cell differentiation |
| activation of MAPK activity |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| growth factor activity |
| positive regulation of protein kinase B signaling |
| cytokine activity |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of protein kinase B signaling |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of growth |
| positive regulation of MAP kinase activity |
| activation of protein kinase activity |
| regulation of developmental growth |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| collagen-containing extracellular matrix |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| response to extracellular stimulus |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| behavior |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of growth |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein homodimerization activity |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | 1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12621
- Expression level (log2 read counts): -2.04
Expression Distribution
GDF15 Expression in NALM6 Cells: -2.04
